Publications

Appleton JP, Dixon M, Woodhouse LJ, Anderson CS, Ankolekar S, Cala L, England TJ, Godolphin PJ, Krishnan K, Mair G, Muir KW, Potter J, Price CI, Randall M, Robinson TG, Roffe C, Rothwell PM, Sandset EC, Saver JL, Siriwardena AN, Wardlaw JM, Sprigg N, Bath PM; RIGHT‐2 Investigators. Pre-hospital transdermal glyceryl trinitrate for transient ischaemic attack: Data from the RIGHT-2 trial. Eur J Neurol. 2024 Dec;31(12):e16502. doi: 10.1111/ene.16502. Epub 2024 Oct 11. PMID: 39392040; PMCID: PMC11554870.

Fontanella A, Li W, Mair G, Antoniou A, Platt E, Armitage P, Trucco E, Wardlaw JM, Storkey A. Development of a deep learning method to identify acute ischaemic stroke lesions on brain CT. Stroke Vasc Neurol. 2024 Dec 25:svn-2024-003372. doi: 10.1136/svn-2024-003372. Epub ahead of print. PMID: 39572171.

Wang Y, Maeda T, You S, Chen C, Liu L, Zhou Z, Robinson TG, Lindley RI, Delcourt C, Mair G, Wardlaw JM, Chalmers JP, Arima H, Huang Y, Kim JS, Lavados PM, Lee TH, Levi C, Parsons MW, Martins SC, Pandian JD, Pontes-Neto OM, Sharma VK, Nguyen TH, Wang J, Wu S, Liu M, Anderson CS, Chen X; ENCHANTED Investigators. Patterns and Clinical Implications of Hemorrhagic Transformation After Thrombolysis in Acute Ischemic Stroke: Results From the ENCHANTED Study. Neurology. 2024 Dec 10;103(11):e210020. doi: 10.1212/WNL.0000000000210020. Epub 2024 Nov 14. PMID: 39541551.

Sleight E, Stringer MS, Clancy U, Arteaga-Reyes C, Jaime Garcia D, Jochems ACC, Wiseman S, Valdes Hernandez M, Chappell FM, Doubal FN, Marshall I, Thrippleton MJ, Wardlaw JM. Association of Cerebrovascular Reactivity With 1-Year Imaging and Clinical Outcomes in Small Vessel Disease: An Observational Cohort Study. Neurology. 2024 Dec 10;103(11):e210008. doi: 10.1212/WNL.0000000000210008. Epub 2024 Nov 5. PMID: 39499872; PMCID: PMC11540458.

Jochems ACC, Muñoz Maniega S, Clancy U, Arteaga Reyes C, Jaime Garcia D, Valdés Hernández MDC, Chappell FM, Barclay G, Jardine C, McIntyre D, Gerrish I, Wiseman S, Stringer MS, Thrippleton MJ, Doubal F, Wardlaw JM. Definitions of white matter hyperintensity change: impact on estimates of progression and regression. Stroke Vasc Neurol. 2024 Oct 2:svn-2024-003300. doi: 10.1136/svn-2024-003300. Epub ahead of print. PMID: 39357898.

Gibson E, Ramirez J, Woods LA, Ottoy J, Berberian S, Scott CJM, Yhap V, Gao F, Coello RD, Valdes Hernandez M, Lang AE, Tartaglia CM, Kumar S, Binns MA, Bartha R, Symons S, Swartz RH, Masellis M, Singh N, Moody A, MacIntosh BJ, Wardlaw JM, Black SE, Lim ASP, Goubran M; ONDRI Investigators, ADNI, CAIN Investigators, colleagues from the Foundation Leducq Transatlantic Network of Excellence. segcsvd_WMH: A Convolutional Neural Network-Based Tool for Quantifying White Matter Hyperintensities in Heterogeneous Patient Cohorts. Hum Brain Mapp. 2024 Dec 15;45(18):e70104. doi: 10.1002/hbm.70104. PMID: 39723488; PMCID: PMC11669893.

Deshpande T, Hannocks MJ, Kapupara K, Samawar SKR, Wachsmuth L, Faber C, Smith C, Wardlaw J, Sorokin L. Microglial activation without peripheral immune cell infiltration characterises mouse and human cerebral small vessel disease. Neuropathol Appl Neurobiol. 2024 Dec;50(6):e13015. doi: 10.1111/nan.13015. PMID: 39543785; PMCID: PMC11618487.

Giarratano Y, Hill EA, Hamid C, Wiseman S, Gray C, Chappell FM, Coello RD, Valdés-Hernández MC, Ballerini L, Stringer MS, Thrippleton MJ, Jaime Garcia D, Liu X, Hewins W, Cheng Y, Black SE, Lim A, Sommer R, Ramirez J, MacIntosh BJ, Brown R, Doubal F, MacGillivray T, Wardlaw JM, Riha R, Bernabeu MO. Retinal microvascular phenotypes can track small vessel disease burden and CPAP treatment effectiveness in obstructive sleep apnoea. J Cereb Blood Flow Metab. 2024 Nov 2:271678X241291958. doi: 10.1177/0271678X241291958. Epub ahead of print. PMID: 39487754; PMCID: PMC11563513.

Stringer MS, Blair GW, Kopczak A, Kerkhofs D, Thrippleton MJ, Chappell FM, Maniega SM, Brown R, Shuler K, Hamilton I, Garcia DJ, Doubal FN, Clancy U, Sakka E, Poliakova T, Janssen E, Duering M, Ingrisch M, Staals J, Backes WH, van Oostenbrugge R, Biessels GJ, Dichgans M, Wardlaw JM; SVDs@target consortium. Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease. Ann Neurol. 2025 Mar;97(3):483-498. doi: 10.1002/ana.27136. Epub 2024 Nov 18. PMID: 39552538; PMCID: PMC11831873.

de Kort FAS, Vinke EJ, van der Lelij EJ, Anblagan D, Bastin ME, Beiser A, Brodaty H, Chaturvedi N, Cheng B, Cox SR, DeCarli C, Enzinger C, Fletcher E, Frayne R, de Groot M, Huang F, Ikram MA, Jiang J, Lam BYK, Maillard P, Mayer C, McCreary CR, Mok V, Maniega SM, Petersen M, Roshchupkin G, Sachdev PS, Schmidt R, Seiler S, Seshadri S, Sudre CH, Thomalla G, Twerenbold R, Valdés Hernández M, Vernooij MW, Wardlaw JM, Wen W, Kuijf HJ, Biessels GJ, Biesbroek JM. Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals. Neurobiol Aging. 2025 Feb;146:38-47. doi: 10.1016/j.neurobiolaging.2024.11.006. Epub 2024 Nov 20. PMID: 39602940.

Li C, Zhang H, Wang J, Han X, Liu C, Li Y, Gong T, Hou T, Wang Y, Cong L, Kalpouzos G, Wardlaw J, Song L, Du Y, Qiu C. Choroid Plexus Volume in Rural Chinese Older Adults: Distribution and Association With Cardiovascular Risk Factors and Cerebral Small Vessel Disease. J Am Heart Assoc. 2024 Nov 5;13(21):e035941. doi: 10.1161/JAHA.124.035941. Epub 2024 Oct 18. PMID: 39424375; PMCID: PMC11935722.

Xu YY, Chappell FM, Valdés Hernández MDC, Arteaga-Reyes C, Clancy U, Garcia DJ, Wiseman S, Stringer MS, Thrippleton M, Cheng Y, Zhang J, Liu X, Jochems ACC, Doubal F, Wardlaw JM; MSS3 Study Group. Prevalence and Clinical Implications of Hemosiderin Deposits in Recent Small Subcortical Infarcts. Neurology. 2024 Nov 26;103(10):e209973. doi: 10.1212/WNL.0000000000209973. Epub 2024 Oct 24. PMID: 39447100; PMCID: PMC11510007.

Muir KW, Ford GA, Ford I, Wardlaw JM, McConnachie A, Greenlaw N, Mair G, Sprigg N, Price CI, MacLeod MJ, Dima S, Venter M, Zhang L, O'Brien E, Sanyal R, Reid J, Sztriha LK, Haider S, Whiteley WN, Kennedy J, Perry R, Lakshmanan S, Chakrabarti A, Hassan A, Marigold R, Raghunathan S, Sims D, Bhandari M, Wiggam I, Rashed K, Douglass C; ATTEST-2 Investigators. Tenecteplase versus alteplase for acute stroke within 4·5 h of onset (ATTEST-2): a randomised, parallel group, open-label trial. Lancet Neurol. 2024 Nov;23(11):1087-1096. doi: 10.1016/S1474-4422(24)00377-6. PMID: 39424558.

Zhao, M., Li, Y., Han, X., Li, C., Wang, P., Wang, J., Hou, T., Wang, Y., Cong, L., Wardlaw, J. M., Launer, L. J., Song, L., Du, Y., & Qiu, C. (2024). Association of enlarged perivascular spaces with cognitive function in dementia-free older adults: A population-based study. Alzheimer's & dementia (Amsterdam, Netherlands), 16(3), e12618. https://doi.org/10.1002/dad2.12618 

Fontanella A, Mair G, Wardlaw J, Trucco E, Storkey A. Diffusion Models for Counterfactual Generation and Anomaly Detection in Brain Images. IEEE Trans Med Imaging. 2024 Sep 13;PP. doi: 10.1109/TMI.2024.3460391. Epub ahead of print. PMID: 39269801.

Gadd DA, Smith HM, Mullin D, Chybowska O, Hillary RF, Kimenai DM, Bernabeu E, Cheng Y, Fawns-Ritchie C, Campbell A, Page D, Taylor A, Corley J, Del C Valdés-Hernández M, Maniega SM, Bastin ME, Wardlaw JM, Walker RM, Evans KL, McIntosh AM, Hayward C, Russ TC, Harris SE, Welsh P, Sattar N, Cox SR, McCartney DL, Marioni RE. DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain. Clin Epigenetics. 2024 Sep 10;16(1):124. doi: 10.1186/s13148-024-01734-7. PMID: 39256775; PMCID: PMC11389299.

Lorenzini L, Maranzano A, Ingala S, Collij LE, Tranfa M, Blennow K, Di Perri C, Foley C, Fox NC, Frisoni GB, Haller S, Martinez-Lage P, Mollison D, O'Brien J, Payoux P, Ritchie C, Scheltens P, Schwarz AJ, Sudre CH, Tijms BM, Verde F, Ticozzi N, Silani V, Visser PJ, Waldman A, Wolz R, Chételat G, Ewers M, Wink AM, Mutsaerts H, Gispert JD, Wardlaw JM, Barkhof F. Association of Vascular Risk Factors and Cerebrovascular Pathology With Alzheimer Disease Pathologic Changes in Individuals Without Dementia. Neurology. 2024 Oct 8;103(7):e209801. doi: 10.1212/WNL.0000000000209801. Epub 2024 Sep 17. PMID: 39288341; PMCID: PMC11450612.

Kancheva AK, Lyall DM, Millard L, Wardlaw JM, Quinn TJ. Clinical Phenotypes Associated With Cerebral Small Vessel Disease: A Study of 45,013 UK Biobank Participants. Neurology. 2024 Oct 22;103(8):e209919. doi: 10.1212/WNL.0000000000209919. Epub 2024 Sep 26. PMID: 39321409.

Viengkhou, B., Hayashida, E., McGlasson, S., Emelianova, K., Forbes, D., Wiseman, S., Wardlaw, J., Verdillo, R., Irani, S. R., Duffy, D., Piehl, F., Loo, L., Pagenstecher, A., Neely, G. G., Crow, Y. J., Campbell, I. L., Hunt, D. P. J., & Hofer, M. J. (2024). The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies. Immunity, 57(7), 1696–1709.e10. https://doi.org/10.1016/j.immuni.2024.05.017 

Zhang, J., Chen, H., Wang, J., Huang, Q., Xu, X., Wang, W., Xu, W., Guan, Y., Liu, J., Wardlaw, J. M., Deng, Y., Xie, F., & Li, B. (2024). Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 20(6), 3931–3942. https://doi.org/10.1002/alz.13845 

Menze I, Bernal J, Kaya P, Aki Ç, Pfister M, Geisendörfer J, Yakupov R, Coello RD, Valdés-Hernández MDC, Heneka MT, Brosseron F, Schmid MC, Glanz W, Incesoy EI, Butryn M, Rostamzadeh A, Meiberth D, Peters O, Preis L, Lammerding D, Gref D, Priller J, Spruth EJ, Altenstein S, Lohse A, Hetzer S, Schneider A, Fliessbach K, Kimmich O, Vogt IR, Wiltfang J, Bartels C, Schott BH, Hansen N, Dechent P, Buerger K, Janowitz D, Perneczky R, Rauchmann BS, Teipel S, Kilimann I, Goerss D, Laske C, Munk MH, Sanzenbacher C, Hinderer P, Scheffler K, Spottke A, Roy-Kluth N, Lüsebrink F, Neumann K, Wardlaw J, Jessen F, Schreiber S, Düzel E, Ziegler G. Perivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study. Alzheimers Res Ther. 2024 Oct 31;16(1):242. doi: 10.1186/s13195-024-01603-8. PMID: 39482759; PMCID: PMC11526621.

Page, D., Buchanan, C. R., Moodie, J. E., Harris, M. A., Taylor, A., Valdés Hernández, M., Muñoz Maniega, S., Corley, J., Bastin, M. E., Wardlaw, J. M., Russ, T. C., Deary, I. J., & Cox, S. R. (2024). Examining the neurostructural architecture of intelligence: The Lothian Birth Cohort 1936 study. Cortex; a journal devoted to the study of the nervous system and behavior, 178, 269–286. https://doi.org/10.1016/j.cortex.2024.06.007 

Whittington B, Tzolos E, Joshi S, Bing R, Andrews J, Loganath K, Craig N, Balmforth C, Clark L, Lucatelli C, MacAskill MG, Tavares AAS, Clark T, Mills NL, Nash J, Dey D, Slomka PJ, Koglin N, Stephens AW, Dweck MR, Williams MC, Whiteley W, van Beek EJR, Wardlaw JM, Newby DE. Qualitative and quantitative analysis of 18F-GP1 positron emission tomography in thrombotic cardiovascular disease. Sci Rep. 2024 Nov 5;14(1):26792. doi: 10.1038/s41598-024-77151-w. PMID: 39500930; PMCID: PMC11538255.

Page D, Buchanan CR, Moodie JE, Harris MA, Taylor A, Valdés Hernández M, Muñoz Maniega S, Corley J, Bastin ME, Wardlaw JM, Russ TC, Deary IJ, Cox SR. Examining the neurostructural architecture of intelligence: The Lothian Birth Cohort 1936 study. Cortex. 2024 Sep;178:269-286. doi: 10.1016/j.cortex.2024.06.007. Epub 2024 Jun 26. PMID: 39067180.

Canavero I, Storti B, Marinoni G, De Souza DA, Moro E, Gatti L, Sacco S, Lorenzano S, Sandset EC, Poggesi A, Carrozzini T, Pollaci G, Potenza A, Gorla G, Wardlaw JM, Zedde ML, Bersano A. COVID-19 and stroke in women: impact on clinical, psychosocial and research aspects. Neurol Sci. 2024 Oct;45(10):4647-4655. doi: 10.1007/s10072-024-07716-0. Epub 2024 Aug 6. PMID: 39103735.

Tranfa, M., Lorenzini, L., Collij, L. E., Vállez García, D., Ingala, S., Pontillo, G., Pieperhoff, L., Maranzano, A., Wolz, R., Haller, S., Blennow, K., Frisoni, G., Sudre, C. H., Chételat, G., Ewers, M., Payoux, P., Waldman, A., Martinez-Lage, P., Schwarz, A. J., Ritchie, C. W., … Barkhof, F. (2024). Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure. Annals of clinical and translational neurology, 11(6), 1541–1556. https://doi.org/10.1002/acn3.52071 

Baranyi, G., Buchanan, C. R., Conole, E. L. S., Backhouse, E. V., Maniega, S. M., Hernandez, M. V., Bastin, M. E., Wardlaw, J., Deary, I. J., Cox, S. R., & Pearce, J. (2023). Life-course neighbourhood deprivation and brain structure in older adults: The Lothian Birth Cohort 1936. medRxiv : the preprint server for health sciences, 2023.04.13.23288523. https://doi.org/10.1101/2023.04.13.23288523 

Zhang, J., Chen, H., Wang, J., Huang, Q., Xu, X., Wang, W., Xu, W., Guan, Y., Liu, J., Wardlaw, J. M., Deng, Y., Xie, F., & Li, B. (2024). Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 20(6), 3931–3942. https://doi.org/10.1002/alz.13845 

Meinel, T. R., Wardlaw, J. M., & Kent, D. M. (2024). Is Incidentally Discovered Covert Cerebrovascular Disease Ignorable?. JAMA neurology, 81(5), 437–438. https://doi.org/10.1001/jamaneurol.2023.5456

Jochems ACC, Muñoz Maniega S, Chappell FM, Clancy U, Arteaga C, Jaime Garcia D, Hamilton OKL, Hewins W, Locherty R, Backhouse EV, Barclay G, Jardine C, McIntyre D, Gerrish I, Cheng Y, Liu X, Zhang J, Kampaite A, Sakka E, Valdés Hernández M, Wiseman S, Stringer MS, Thrippleton MJ, Doubal FN, Wardlaw JM. Impact of long-term white matter hyperintensity changes on mobility and dexterity. Brain Commun. 2024 May 7;6(3):fcae133. doi: 10.1093/braincomms/fcae133. PMID: 38715716; PMCID: PMC11074793.

Clancy, U., Kancheva, A. K., Valdés Hernández, M. D. C., Jochems, A. C. C., Muñoz Maniega, S., Quinn, T. J., & Wardlaw, J. M. (2024). Imaging Biomarkers of VCI: A Focused Update. Stroke, 55(4), 791–800. https://doi.org/10.1161/STROKEAHA.123.044171 

Hwai, S. W. C., Wardlaw, J. M., Williams, A., & Doubal, F. N. (2024). What matters to people and families affected by cerebral small vessel disease (SVD)? A qualitative grounded theory investigation. Cerebral circulation - cognition and behavior, 6, 100202. https://doi.org/10.1016/j.cccb.2024.100202 

Wardlaw, J. M., Chabriat, H., de Leeuw, F. E., Debette, S., Dichgans, M., Doubal, F., Jokinen, H., Katsanos, A. H., Ornello, R., Pantoni, L., Pasi, M., Pavlovic, A. M., Rudilosso, S., Schmidt, R., Staals, J., Taylor-Rowan, M., Hussain, S., & Lindgren, A. G. (2024). European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke. European stroke journal, 9(1), 5–68. https://doi.org/10.1177/23969873231219416 

Moodie, J. E., Harris, S. E., Harris, M. A., Buchanan, C. R., Davies, G., Taylor, A., Redmond, P., Liewald, D., Del C Valdés Hernández, M., Shenkin, S., Russ, T. C., Muñoz Maniega, S., Luciano, M., Corley, J., Stolicyn, A., Shen, X., Steele, D., Waiter, G., Sandu-Giuraniuc, A., Bastin, M. E., … Cox, S. R. (2023). General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning. bioRxiv : the preprint server for biology, 2023.03.16.532915. https://doi.org/10.1101/2023.03.16.532915