Find out about our recent scientific publications. Publications 2024 Alzheimer's Association: Diagnosis, Assessment & Disease Monitoring Journal, Volume 16, Issue 3 - July - September 2024 e12618: Association of enlarged perivascular spaces with cognitive function in dementia-free older adults: A population-based study. Authors: Mingqing Zhao, Yuanjing Li, Xiaodong Han, Chunyan Li, Pin Wang, Jiafeng Wang, Tingting Hou, Yongxiang Wang, Lin Cong, Joanna M. Wardlaw, Lenore J. Launer, Lin Song, Yifeng Du, Chengxuan Qiu. First published: 23 July 2024: https://doi.org/10.1002/dad2.12618 Immunity Journal, Volume 57, Issue 7 9 July 2024, pages 1696-1709.e10: The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies. Authors: Barney Viengkhou, Emina Hayashida, Sarah McGlasson, Katie Emelianova, Deborah Forbes, Stewart Wiseman, Joanna Wardlaw, Rovin Verdillo, Sarosh R. Irani, Darragh Duffy, Fredrik Piehl, Lipin Loo, Axel Pagenstecher, G. Greg Neely, Yanick J. Crow, Iain L. Campbell, David P.J. Hunt, Markus J. Hofer. Published: 14 June 2024: https://doi.org/10.1016/j.immuni.2024.05.017 Alzheimer's Association: Alzheimer's & Dementia Journal, Volume 20, Issue 6, June 2024, pages 3931-3942: Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's disease. Authors: Junfang Zhang, Haijuan Chen, Jie Wang, Qi Huang, Xiaomeng Xu, Wenjing Wang, Wei Xu, Yihui Guan, Jun Liu, Joanna M Wardlaw, Yulei Deng, Fang Xie, Binyin Li. First published: 22 April 2024: https://doi.org/10.1002/alz.13845 Danielle Page, Colin R. Buchanan, Joanna E. Moodie et.al (2024) Examining the neurostructural architecture of intelligence: The Lothian Birth Cohort 1936 study Mario Tranfa, Luigi Lorenzini, Lyduine E. Collij et.al (2024) Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter Microstructure Gergő Baranyi, Colin R. Buchanan, Eleanor L. S. Conole, Ellen V. Backhouse, et.al (2024) Life-course neighbourhood deprivation and brain structure in older adults: the Lothian Birth Cohort 1936 Junfang Zhang, Haijuan Chen, Jie Wang, et.al (2024) Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's disease Thomas R Meinel, Joanna M. Wardlaw, David M Kent (2024) Is Incidentally Discovered Covert Cerebrovascular Disease Ignorable? Una Clancy, Angelina K. Kancheva, Maria del C. Valdés Hernández, Angela C.C. Jochems, Susana Muñoz Maniega, Terence J. Quinn and Joanna M. Wardlaw Imaging Biomarkers of VCI: A Focused Update Sophia Wong Ching Hwai, Joanna M. Wardlaw, Anna Williams, Fergus N. Doubal (2024) What matters to people and families affected by cerebral small vessel disease (SVD)? A qualitative grounded theory investigation Joanna M Wardlaw Hugues Chabriat, Frank-Erik de Leeuw et al (2024) European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke Joanna E Moodie, Sarah E Harris et al (2024) General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning Jochems, Maniega, Clancy et al (2024) Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress Publications 2023 Vacek, Mair et al (2023) Evaluating artificial intelligence software for delineating hemorrhage extent on CT brain imaging in stroke Burke, Engelmann et al (2023) An Open-Source Deep Learning Algorithm for Efficient and Fully Automatic Analysis of the Choroid in Optical Coherence Tomography Dehsarvi, Warsity et al (2023) Characterising the neurobiological mechanisms of action of exercise and cognitive behavioural interventions for rheumatoid arthritis fatigue: an MRI brain study Sri, Greenstein et al (2023) A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementia Kopczak, Stringer et al (2023) Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial Sennfält et al (2023) Visualising and semi-quantitatively measuring brain fluid pathways, including meningeal lymphatics, in humans using widely available MRI techniques Alzahrani et al (2023) Assessing Brain Tissue Viability on Nonenhanced Computed Tomography After Ischemic Stroke Aribisala et al. (2023) Sleep quality, perivascular spaces and brain health markers in ageing - A longitudinal study in the Lothian Birth Cohort 1936 Boots et al. (2023) Shaping the risk for late-life neurodegenerative disease: A systematic review on prenatal risk factors for Alzheimer’s disease-related volumetric brain biomarkers Clancy et al (2023) Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults? Evidence from the Lothian Birth Cohort 1936 Clancy et al. (2023) Neuropsychiatric symptoms as a sign of small vessel disease progression in cognitive impairment Duering et al. (2023) Neuroimaging standards for research into small vessel disease—advances since 2013 Exalto et al. (2023) Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic Stroke Gibson et al. (2023) Towards equality: gender representation at the Royal College of Radiologists’ Annual Scientific Meeting 2014-2021 Humphreys and Hernandez (2023) Impact of polycyclic aromatic hydrocarbon exposure on cognitive function and neurodegeneration in humans: A systematic review and meta-analysis Kopczak et al. (2023) The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial Lam et al (2022) The global burden of cerebral small vessel disease in low- and middle-income countries - a systematic review and meta-analysis Liebeskind and Wardlaw (2023) Imaging Advances in Stroke: Use of Advanced Neurovascular Imaging or Disruptive Innovation With Artificial Intelligence? Rudilosso et al. (2023) Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel disease Sáenz de Villaverde Cortabarría et al. (2023) Paranasal sinuses opacification on magnetic resonance imaging in relation to brain health in sporadic small vessel disease - Systematic review and pilot analysis Schreiber et al. (2023) Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity Sennfalt et al. (2023) Visualising and semi-quantitatively measuring brain fluid pathways, including meningeal lymphatics, in humans using widely available MRI techniques Siedlinski et al. (2023) Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressure Valdes Hernandez et al. (2023) Paranasal sinus occupancy assessed from magnetic resonance images-associations with clinical indicators in patients with systemic lupus erythematosus Wang et al. (2023) Baseline brain imaging signs in patients with ischaemic stroke by the presence of atrial fibrillation: the ENCHANTED trial Wardlaw et al. (2023) Even more benefit with endovascular treatment for patients with acute ischaemic stroke: MR CLEAN-LATE Wardlaw et al. (2023) Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel DiseaseThe Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial Whittington et al. (2023) Noninvasive In Vivo Thrombus Imaging in Patients With Ischemic Stroke or Transient Ischemic Attack Publications 2022 2023 Alzahrani et al (2023) Assessing Brain Tissue Viability on Nonenhanced Computed Tomography After Ischemic Stroke Clancy et al (2023) Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults? Evidence from the Lothian Birth Cohort 1936 Clancy et al. (2023) Neuropsychiatric symptoms as a sign of small vessel disease progression in cognitive impairment Lam et al (2022) The global burden of cerebral small vessel disease in low- and middle-income countries - a systematic review and meta-analysis December Persson et al. (2022) Could dexmedetomidine be repurposed as a glymphatic enhancer? Lahna et al. (2022) Venous Collagenosis as Pathogenesis of White Matter Hyperintensity November Bernal et al (2022) Assessment of perivascular space filtering methods using a three-dimensional computational model October Nanayakkara et al (2022) Increased brain volumetric measurement precision from multi-site 3D T1-weighted 3 T magnetic resonance imaging by correcting geometric distortions van den Brink et al. (2022) CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRI Wiseman et al (2022) Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel disease Lam er al (2022) The global burden of cerebral small vessel disease in low- and middle-income countries - a systematic review and meta-analysis September Jochems et al. (2022) Longitudinal Changes of White Matter Hyperintensities in Sporadic Small Vessel Disease: A Systematic Review and Meta-analysis August Charidimou et al (2022) The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI–neuropathology diagnostic accuracy study Ball et al (2022) Predictors of post-stroke cognitive impairment using acute structural MRI neuroimaging: A systematic review and meta-analysis Quick et al (2022) Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model Whiteley et al. (2022) Clinical Diagnosis and Magnetic Resonance Imaging in Patients With Transient and Minor Neurological Symptoms: A Prospective Cohort Study Markus et al. (2022) Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE) A Review Barnes et al. (2022) Topological relationships between perivascular spaces and progression of white matter hyperintensities: A pilot study in a sample of the Lothian Birth Cohort 1936 Li et al. (2022) Deep attention super-resolution of brain magnetic resonance images acquired under clinical protocols Mair et al. (2022) External Validation of e-ASPECTS Software for Interpreting Brain CT in Stroke Jochems et al. (2022) Associations of Peak-Width Skeletonized Mean Diffusivity and Post-Stroke Cognition July Wardlaw et al (2022) Accuracy of Automated Computer-Aided Diagnosis for Stroke Imaging: A Critical Evaluation of Current Evidence Lorenzini et al (2022) The Open-Access European Prevention of Alzheimer’s Dementia (EPAD) MRI dataset and processing workflow Lee et al (2022) Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labeling Ball et al. (2022) Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysis June Zhou et al (2002) Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure target Monte et al (2022) Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imaging Ibitoye et al (2022) A link between frontal white matter integrity and dizziness in cerebral small vessel disease Whittaker et al (2022) Systematic Review of Cerebral Phenotypes Associated With Monogenic Cerebral Small-Vessel Disease Kaczynski et al (2022) 18 F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular Syndrome Mishra et al (2022) Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate May Mishra et al (2022) Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate Rudilosso et al (2022) Prevalence and Significance of the Vessel-Cluster Sign on Susceptibility-Weighted Imaging in Patients With Severe Small Vessel Disease Quick et al (2022) Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model April Zhao et al (2022) Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation Biesbroek et al (2022) Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke Brouwer et al (2022) Genetic variants associated with longitudinal changes in brain structure across the lifespan Wardlaw et al (2022) Accuracy of Automated Computer-Aided Diagnosis for Stroke Imaging: A Critical Evaluation of Current Evidence Luciano et al (2022) Mediterranean-Type Diet and Brain Structural Change from 73 to 79 Years in the Lothian Birth Cohort 1936 Biesbroek et al (2022) Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic stroke Jochems et al (2022) Contribution of white matter hyperintensities to ventricular enlargement in older adults Wardlaw & Liebeskind (2022)Not Just Blood: Brain Fluid Systems and Their Relevance to Cerebrovascular Diseases Sliz et al (2022) Circulating Metabolome and White Matter Hyperintensities in Women and Men Clancy et al (2022) Impact of Small Vessel Disease Progression on Long-term Cognitive and Functional Changes After Stroke March Meinel et al (2022) Letter by Meinel et al. regarding article, "Incidental findings on 3 T neuroimaging: cross‑sectional observations from the population‑based Rhineland Study" Wheater et al (2022) DNA methylation in relation to gestational age and brain dysmaturation in preterm infants February Wiseman et al (2022) Measuring axial length of the eye from magnetic resonance brain imaging Clancy et al (2022) Impact of Small Vessel Disease Progression on Long-term Cognitive and Functional Changes After Stroke Fletcher et al (2022) Thoracic Aortic 18 F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular Disease Chen et al (2022) Perivascular space in Parkinson's disease: Association with CSF amyloid/tau and cognitive decline Craig et al (2022) Prevalence of dementia in ischaemic or mixed stroke populations: systematic review and meta-analysis Barisano et al (2022) Blood-brain barrier link to human cognitive impairment and Alzheimer's Disease Wardlaw, Benveniste and Williams (2022) Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies January Tunnage et al (2022) Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial. Sliz et al (2022) Circulating Metabolome and White Matter Hyperintensities in Females and Males McCartney et al (2022) Blood-based epigenome-wide analyses of cognitive abilities Chen et al (2022) Perivascular space in Parkinson's disease: Association with CSF amyloid/tau and cognitive decline Moullaali et al (2022) Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data Publications 2021 December Blair et al (2021) Effects of Cilostazol and Isosorbide Mononitrate on Cerebral Hemodynamics in the LACI-1 Randomized Controlled Trial Conosole et al (2021) DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging November Moullaali et al (2021) Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data Stringer et al (2021) Tracer kinetic assessment of blood-brain barrier leakage and blood volume in cerebral small vessel disease: Associations with disease burden and vascular risk factors October Wardlaw et al (2021) Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical Studies Zhang et al (2021) Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel disease de Havenon et al (2021) Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and Possibilities Chagnot et al (2021) Magnetic Resonance Imaging of Blood-Brain Barrier permeability in Dementia Jiménez-Sánchez et al (2021) Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis Green C et al (2021) Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland September Vynckier et al (2021) Phenotypes of Chronic Covert Brain Infarction in Patients With First-Ever Ischemic Stroke: A Cohort Study Ball et al (2021) Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysis Backhouse et al (2021) Early life predictors of late life cerebral small vessel disease in four prospective cohort studies Shi et al (2021) Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individuals Oh et al (2021) Fixel-Based Analysis Effectively Identifies White Matter Tract Degeneration in Huntington’s Disease Wardlaw et al (2021) Reply to: Rethink the classical view of cerebrospinal fluid production Hamilton et al (2021) Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort Al-Shahi Salman et al (2021) Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral HemorrhageExtended Follow-up of the RESTART Randomized Clinical Trial SoSTART Collaboration (2021) Effects of oral anticoagulation for atrial fibrillation after spontaneous intracranial haemorrhage in the UK: a randomised, open-label, assessor-masked, pilot-phase, non-inferiority trial August Xia et al (2021) Early decompressive hemicraniectomy in thrombolyzed acute ischemic stroke patients from the international ENCHANTED trial Weather et al (2021) Birth weight is associated with brain tissue volumes seven decades later but not with MRI markers of brain ageing July Wardlaw (2021) A Stroke Is a Stroke, With or Without a Visible Infarct Procter et al (2021) Interplay between brain pericytes and endothelial cells in dementia Habota et al (2021) Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments [version 2; peer review: 2 approved] Bernal et al (2021) Selective Motion Artefact Reduction via Radiomics and k-space Reconstruction for Improving Perivascular Space Quantification in Brain Magnetic Resonance Imaging Blair et al (2021) Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project Wardlaw et al (2021) Reply to: Rethink the classical view of cerebrospinal fluid production Hamilton et al (2021) Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936 June Hamilton & Wardlaw (2021) Response to Schroeter ML, Letter, Small vessel disease and social cognition Stringer et al (2021) A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel Disease Wiegertjes et al (2021) Diffusion-weighted imaging lesions and risk of recurrent stroke after intracerebral haemorrhage Zhou et al (2021) Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure target Portilla-Fernandez et al (2021) Meta-analysis of epigenome-wide association studies of carotid intima-media thickness Zhu et al (2021) Alzheimer's pathogenic mechanisms and underlying sex difference Datasets Valdés Hernández et al (2021) White Matter Hyperintensities Evolution Patterns 1 Year Post-lacunar Stroke and their association with post-stroke cognition Castorina et al (2021) Metrics for quality control of results from super-resolution machine-learning algorithms – Data extracted from publications in the period 2017- May 2021 Morrsison & Valdés Hernández (2021) Systematic Review and Meta-Analysis on incidence and risk of stroke in individuals with long-term exposure to air pollutants May Morrison et al (2021) Potential recruitment into a clinical trial of vascular secondary prevention medications in cerebral small vessel disease, based on concomitant medication use Stewart et al (2021) Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis Manning et al (2021) Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakage Wardlaw et al (2021) ESO Guideline on covert cerebral small vessel disease van der Brink et al (2021) Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the “ZOOM@SVDs” study Buchanan et al (2021) Comparison of structural MRI brain measures between 1.5 and 3 T: Data from the Lothian Birth Cohort 1936 Datasets Bernal (2021) Systematic review of signal post-processing methods in blood-brain barrier dysfunction assessments via dynamic-contrast enhanced magnetic resonance imaging Humphreys & Valdés Hernández (2021) Systematic Review and Meta-Analysis on the Impact of Polycyclic Aromatic Hydrocarbons Exposure in Cognitive Function and Neurodegeneration in Humans Valdés Hernández (2021) Human Brain Atlases across the lifespan – Anatomical Segmentations April Madole et al (2021) Aging-Sensitive Networks Within the Human Structural Connectome Are Implicated in Late-Life Cognitive Declines Bernal et al (2021) A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage Ingala et al (2021) Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort March Valdes-Hernandez et al (2021) Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar Stroke Taylor et al (2021) Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studies Valdes-Hernandez et al (2021) Lacunar Stroke Lesion Extent and Location and White Matter Hyperintensities Evolution 1 Year Post-lacunar Stroke Clancy et al (2021) Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis Liebeskind & Wardlaw (2021). Imaging advances: acute-on-chronic stroke February Verdelho et al (2021) Cognitive impairment in patients with cerebrovascular disease: A white paper from the ESO Dementia Committee Verdelho et al (2021) Cerebrovascular disease in patients with cognitive impairment: A white paper from the ESO dementia committee – A practical point of view with suggestions for the management of cerebrovascular diseases in memory clinics Zhou et al (2021) Low- versus Standard-dose Alteplase in Acute Lacunar Ischemic Stroke: The ENCHANTED Trial Green et al (2021) Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder Rodriguez et al (2021) Association between Computed Tomographic Biomarkers of Cerebral Small Vessel Diseases and Long-Term Outcome after Spontaneous Intracerebral Hemorrhage Stringer et al (2021) A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease Papanastasiou et al (2021) Pharmacokinetic modelling for the simultaneous assessment of perfusion and 18F-flutemetamol uptake in cerebral amyloid angiopathy using a reduced PET-MR acquisition time: Proof of concept Expand all Collapse all View all publication of the Small Vessel Disease Research group at the Edinburgh Research Explorer Small Vessel Disease Research publications- Edinburgh Research Explorer (external link) Books / Book chapters Gorelick PB, Testai FD, Hankey GJ, Wardlaw JM (2021). "Hankey's Clinical Neurology" (3rd Edition) Link 20% discount available with a flyer Doubal F, Poggesi A, Pantoni L, Wardlaw JM (2020). Section 4 Vascular Disease, Chapter 21, Small vessel disease. In Brayne C, Feigin V, Launer L, Logroscino G, eds. Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology. Oxford University Press, Oxford, 2020. DOI link: 10.1093/med/9780198749493.001.0001 Rekik I, Adeli E, Park SH, Valdés Hernández M del C (2020). Predictive Intelligence in Medicine. Third International Workshop, PRIME 2020, Held in Conjunction with MICCAI 2020. Link Protocol research publications INVESTIGATE@SVDs study protocol Blair et al (2021) Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project. Publication link Mild Stroke Study 3 (MSS3) protol research publication Clancy et al (2020). Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3. Publication link - Edinburgh Research Explorer LACI-2 protocol research publication Wardlaw et al (2020). Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease. Publication link - Edinburgh Research Explorer LACI-1 publication presenting key results Blair et al (2019). Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial. Publication link - Edinburgh Reserach Explorer Rates, Risks and Routes to Reduce Vascular Dementia (R4VaD) key publication Backhouse et al (2019). Rates, risks and routes to reduce vascular dementia (R4VAD). Publication link Read more about our research Our research Systematic reviews 2021 Ball et al (2021) Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysis Publication link Clancy et al (2021) Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis. Publication link Stringer et al (2021). A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease. Publication link Morgan et al (2021). 4D flow MRI for non-invasive measurement of blood flow in the brain: a systematic review. Publication link Sleight (2021). Cerebrovascular reactivity measurement using magnetic resonance imaging: a systematic review. Publication link Verdelho et al (2021). Cerebrovascular disease in patients with cognitive impairment: A white paper from the ESO Dementia Committee. Publication link Best et al (2021). Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Publication link Madole et al (2021). Aging-sensitive networks within the human structural connectome are implicated in late-life cognitive declines. Publication link 2020 Hamilton et al. (2020). Cognitive impairments in sporadic cerebral small vessel disease (SVD): a systematic review and meta-analysis of cohorts with stroke, dementia and non-clinical presentations of SVD. Publication link Zhang et al (2020). The application of optical coherence tomography angiography in cerebral small vessel disease, ischemic stroke, and dementia: a systematic review. Publication link Doubal et al (2020). Response by Doubal et al to Letter Regarding Article, "Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis. Publication link Hamilton et al (2020). Cognitive impairment in sporadic cerebral small vessel disease: a systematic review and meta‐analysis. Publication link Balakrishnan et al (2020) Automatic segmentation of white matter hyperintensities from brain magnetic resonance images in the era of deep learning and big data – a systematic review. Publication link Appleton et al (2020). Intracranial bleeding after reperfusion therapy in acute ischaemic stroke patients randomized to glyceryl trinitrate vs. control: An individual patient data meta-analysis. Publication link Saba et al (2020). Multi-national survey of current practice from imaging to treatment of atherosclerotic carotid stenosis. Publication link Stewart et al (2020). Associations between white matter hyperintensity burden, cerebral blood flow and transit time in small vessel disease: an updated meta-analysis. Publication link Clancy et al (2020). Clinical management of cerebral small vessel disease: a call for a holistic approach. Publication link Wardlaw et al (2020). Brain atrophy in cerebral small vessel diseases: extent, consequences, technical limitations and perspectives: the HARNESS initiative. Publication link McHutchison et al (2020). Cilostazol for secondary prevention of stroke and cognitive decline: Systematic review and meta-analysis. Publication link Wheater et al (2020). DNA methylation and brain structure and function across the life course: A systematic review. Publication link Sweeney et al (2020). Perivascular Spaces in the Brain: anatomy, physiology, and pathology. Publication link 2019 Francis et al (2019). Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis. Publication link Moullaali et al (2019). Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood pressure in Acute Stroke Collaboration (BASC). Publication link Smith et al (2019). Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration. Publication link Thrippleton et al (2019). Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations. Publication link Lindekleiv et al (2019). Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke. Publication link Wardlaw et al (2019). Small vessel disease: mechanisms and clinical implications. Publication link 2018 Backhouse et al (2018). Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis. Publication link Pellegrini et al (2018) Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review. Publication link Shi et al (2018). Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review. Publication link Georgakis et al (2018). WMH and long-term outcomes in ischemic stroke: a systematic review and meta-analysis. Publication link Gibson et al (2018). Potentially serious incidental findings on brain and body magnetic resonance imaging of apparently asymptomatic adults: systematic review and meta-analysis. Publication link 2017 Abbott et al (2017). Optimizing the definitions of stroke, transient ischemic attack, and infarction for research and application in clinical practice. Publication link Van Veluw et al (2017). Detection, risk factors, and functional consequences of cerebral microinfarcts. Publication link Mollison et al (2017). The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis. Publication link Blair et al (2017). Advanced neuroimaging of cerebral small vessel disease. Publication link Dickie et al (2017). Whole brain magnetic resonance image atlases: a systematic review of existing atlases and caveats for use in population imaging. Publication link Also republished as a chapter in the following e-book: Dojat M, Niessen W, Kennedy DN eds. MAPPING: MAnagement and Processing of Images for Population ImagiNG. Lausanne: Frontiers Media SA 2017. Publication link Backhouse et al (2017). Early life risk factors for cerebrovascular disease: A systematic review and meta-analysis. Publication link McGrory et al (2017). The application of retinal fundus camera imaging in dementia: A systematic review. Publication link Read other systematic reviews - SVD Research Edinburgh Research Explorer Meta-analyses 2021 Stewart et al (2021) Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis. Publication link Clancy et al (2021) Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis. Publication link Jimenez Sanchez et al (2021). Sex differences in cerebral small vessel disease: a systematic review and meta-analysis. Publication link 2020 Stewart et al (2020). Associations between white matter hyperintensity burden, cerebral blood flow and transit time in small vessel disease: an updated meta-analysis. Publication link Hamilton et al (2020). Cognitive impairments in sporadic cerebral small vessel disease (SVD): a systematic review and meta-analysis of cohorts with stroke, dementia and non-clinical presentations of SVD. Publication link McHutchison et al (2020). Cilostazol for secondary prevention of stroke and cognitive decline: Systematic review and meta-analysis. Publication link Hamilton et al (2020). Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis. Publication link Appleton et al (2020). Intracranial bleeding after reperfusion therapy in acute ischaemic stroke patients randomized to glyceryl trinitrate vs. control: An individual patient data meta-analysis. Publication link 2019 Jia et al (2019). Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group. Publication link Moullaali et al (2019). Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood pressure in Acute Stroke Collaboration (BASC). Publication link Francis et al (2019). Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis. Publication link 2018 Gibson et al (2018). Potentially serious incidental findings on brain and body magnetic resonance imaging of apparently asymptomatic adults: systematic review and meta-analysis. Publication link Hacke et al (2018). Effects of alteplase for acute stroke according to criteria defining the European Union and United States marketing authorizations: Individual-patient-data meta-analysis of randomized trials. Publication link Backhouse et al (2018). Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis. Publication link Georgakis et al (2018). WMH and long-term outcomes in ischemic stroke: a systematic review and meta-analysis. Publication link Gibson et al (2018). Potentially serious incidental findings on brain and body magnetic resonance imaging of apparently asymptomatic adults: systematic review and meta-analysis. Publication link 2017 McHutchison et al (2017). Education, socioeconomic status and intelligence in childhood and stroke risk in later life: A meta-analysis. Publication link Mollison et al (2017). The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis. Publication link Backhouse et al (2017). Early life risk factors for cerebrovascular disease: A systematic review and meta-analysis. Publication link Wiseman et al (2018). Fatigue and cognitive function in systemic lupus erythematosus: associations with white matter microstructural damage. A diffusion tensor MRI study and meta-analysis. Publication link Woodhouse et al (2018). Continuing or temporarily stopping prestroke antihypertensive medication in acute stroke: and individual patient data meta-analysis. Publication link Read other meta-analyses - SVD Research Edinburgh Research Explorer Reviews 2021 Verdelho et al (2021). Cognitive impairment in patients with cerebrovascular disease: A white paper from the ESO Dementia Committee. Publication link Liebeskind DS & Wardlaw JM (2021). Imaging Advances: Acute-on-Chronic Stroke. Stroke In Press (Impact factor for 2019: 7.190) Publication link 2020 Wardlaw et al (2020).Perivascular spaces in the brain: anatomy, physiology and pathology. Publication link Quick et al (2020). A vessel for change: endothelial dysfunction in cerebral small vessel disease. Publication link Pan et al (2020). A new dawn of preventing dementia by preventing cerebrovascular diseases. Publication link Benveniste et al (2020). The glymphatic system and its role in cerebral homeostasis. Publication link Mok et al (2020). Tackling challenges in care of alzheimer’s disease and other dementias amid the COVID-19 pandemic, now and in the future. Publication link 2019 Hachinski et al (2019). Preventing dementia by preventing stroke: The Berlin Manifesto. Publication link Hachinski et al (2019). Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto. Publication link Wardlaw et al (2019). Longer time windows, refining benefit, and prevention targets lifestyle. Publication link 2018 Wardlaw JM & William M(2018). Feinberg award for excellence in clinical stoke: Small vessel disease; a big problem, but fixable. Publication link Ten Kate et al (2018). Secondary prevention of Alzheimer’s dementia – neuroimaging contributions. Publication link Sweeney et al (2018). Vascular dysfunction – the disregarded partner of Alzheimer’s disease. Publication link Debette et al (2018). Fourth European stroke science workshop. Publication link Brown et al (2018). Understanding the role of the perivascular space in cerebral small vessel disease. Publication link Benveniste et al (2018). The glymphatic system and waste clearance with brain aging. (Impact Factor for 2019 – 3.540) Publication link 2017 Cameron et al (2018). Lateral thinking - interocular symmetry and asymmetry in neurovascular patterning, in health and disease. Publication link Read other reviews - SVD Research Edinburgh Research Explorer Expand all Collapse all Related links View information related to our research projects Our research This article was published on 2024-08-27
