Apr 2016: We are pleased to announce that anonymised IST3 trial data are now available for use by other researchers. The third International Stroke Trial was the largest-ever randomised controlled trial of intravenous thrombolysis (clot-busting) treatment for patients with acute ischaemic stroke.The publication of the key reports from the trial have been highly cited and have had a significant impact on clinical practice.In accordance with its published plan to make the trial data available to bona fide researchers, the IST-3 collaborative group has lodged an anonymised version of the dataset in Edinburgh Datashare. Image Application for access to this data is via a controlled access process, which is detailed on the IST3 page on Edinburgh Datashare.This step meets the data sharing requirements of the principal funder of the trial, the UK MRC, and the recommendations of the ICMJE, and is in accordance with the MRC Methodology Hubs’ recent publication on good practice principles for sharing individual participant data from publicly funded clinical trials (Tudur Smith et al., BMC Med 2015;13: 298).Related linksLetter in the Lancet announcing the data releaseIST3 clinical trial websiteIST3 results publication in the Lancet Publication date 11 Apr, 2016
