Find out about our recent scientific publications. Publications 2024Alzheimer's Association: Diagnosis, Assessment & Disease Monitoring Journal, Volume 16, Issue 3 - July - September 2024 e12618: Association of enlarged perivascular spaces with cognitive function in dementia-free older adults: A population-based study. Authors: Mingqing Zhao, Yuanjing Li, Xiaodong Han, Chunyan Li, Pin Wang, Jiafeng Wang, Tingting Hou, Yongxiang Wang, Lin Cong, Joanna M. Wardlaw, Lenore J. Launer, Lin Song, Yifeng Du, Chengxuan Qiu. First published: 23 July 2024: https://doi.org/10.1002/dad2.12618Immunity Journal, Volume 57, Issue 7 9 July 2024, pages 1696-1709.e10: The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies. Authors: Barney Viengkhou, Emina Hayashida, Sarah McGlasson, Katie Emelianova, Deborah Forbes, Stewart Wiseman, Joanna Wardlaw, Rovin Verdillo, Sarosh R. Irani, Darragh Duffy, Fredrik Piehl, Lipin Loo, Axel Pagenstecher, G. Greg Neely, Yanick J. Crow, Iain L. Campbell, David P.J. Hunt, Markus J. Hofer. Published: 14 June 2024: https://doi.org/10.1016/j.immuni.2024.05.017Alzheimer's Association: Alzheimer's & Dementia Journal, Volume 20, Issue 6, June 2024, pages 3931-3942: Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's disease. Authors: Junfang Zhang, Haijuan Chen, Jie Wang, Qi Huang, Xiaomeng Xu, Wenjing Wang, Wei Xu, Yihui Guan, Jun Liu, Joanna M Wardlaw, Yulei Deng, Fang Xie, Binyin Li. First published: 22 April 2024: https://doi.org/10.1002/alz.13845Danielle Page, Colin R. Buchanan, Joanna E. Moodie et.al (2024) Examining the neurostructural architecture of intelligence: The Lothian Birth Cohort 1936 studyMario Tranfa, Luigi Lorenzini, Lyduine E. Collij et.al (2024) Alzheimer's Disease and Small Vessel Disease Differentially Affect White Matter MicrostructureGergő Baranyi, Colin R. Buchanan, Eleanor L. S. Conole, Ellen V. Backhouse, et.al (2024) Life-course neighbourhood deprivation and brain structure in older adults: the Lothian Birth Cohort 1936Junfang Zhang, Haijuan Chen, Jie Wang, et.al (2024) Linking white matter hyperintensities to regional cortical thinning, amyloid deposition, and synaptic density loss in Alzheimer's diseaseThomas R Meinel, Joanna M. Wardlaw, David M Kent (2024) Is Incidentally Discovered Covert Cerebrovascular Disease Ignorable? Una Clancy, Angelina K. Kancheva, Maria del C. Valdés Hernández, Angela C.C. Jochems, Susana Muñoz Maniega, Terence J. Quinn and Joanna M. Wardlaw Imaging Biomarkers of VCI: A Focused UpdateSophia Wong Ching Hwai, Joanna M. Wardlaw, Anna Williams, Fergus N. Doubal (2024) What matters to people and families affected by cerebral small vessel disease (SVD)? A qualitative grounded theory investigationJoanna M Wardlaw Hugues Chabriat, Frank-Erik de Leeuw et al (2024) European stroke organisation (ESO) guideline on cerebral small vessel disease, part 2, lacunar ischaemic stroke Joanna E Moodie, Sarah E Harris et al (2024) General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioningJochems, Maniega, Clancy et al (2024) Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress Publications 2023Vacek, Mair et al (2023) Evaluating artificial intelligence software for delineating hemorrhage extent on CT brain imaging in strokeBurke, Engelmann et al (2023) An Open-Source Deep Learning Algorithm for Efficient and Fully Automatic Analysis of the Choroid in Optical Coherence TomographyDehsarvi, Warsity et al (2023) Characterising the neurobiological mechanisms of action of exercise and cognitive behavioural interventions for rheumatoid arthritis fatigue: an MRI brain studySri, Greenstein et al (2023) A multi-disciplinary commentary on preclinical research to investigate vascular contributions to dementiaKopczak, Stringer et al (2023) Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial Sennfält et al (2023) Visualising and semi-quantitatively measuring brain fluid pathways, including meningeal lymphatics, in humans using widely available MRI techniquesAlzahrani et al (2023) Assessing Brain Tissue Viability on Nonenhanced Computed Tomography After Ischemic StrokeAribisala et al. (2023) Sleep quality, perivascular spaces and brain health markers in ageing - A longitudinal study in the Lothian Birth Cohort 1936Boots et al. (2023) Shaping the risk for late-life neurodegenerative disease: A systematic review on prenatal risk factors for Alzheimer’s disease-related volumetric brain biomarkersClancy et al (2023) Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults? Evidence from the Lothian Birth Cohort 1936Clancy et al. (2023) Neuropsychiatric symptoms as a sign of small vessel disease progression in cognitive impairmentDuering et al. (2023) Neuroimaging standards for research into small vessel disease—advances since 2013Exalto et al. (2023) Sex Differences in Poststroke Cognitive Impairment: A Multicenter Study in 2343 Patients With Acute Ischemic StrokeGibson et al. (2023) Towards equality: gender representation at the Royal College of Radiologists’ Annual Scientific Meeting 2014-2021Humphreys and Hernandez (2023) Impact of polycyclic aromatic hydrocarbon exposure on cognitive function and neurodegeneration in humans: A systematic review and meta-analysisKopczak et al. (2023) The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trialLam et al (2022) The global burden of cerebral small vessel disease in low- and middle-income countries - a systematic review and meta-analysisLiebeskind and Wardlaw (2023) Imaging Advances in Stroke: Use of Advanced Neurovascular Imaging or Disruptive Innovation With Artificial Intelligence?Rudilosso et al. (2023) Blood-brain barrier leakage hotspots collocating with brain lesions due to sporadic and monogenic small vessel diseaseSáenz de Villaverde Cortabarría et al. (2023) Paranasal sinuses opacification on magnetic resonance imaging in relation to brain health in sporadic small vessel disease - Systematic review and pilot analysisSchreiber et al. (2023) Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular IntegritySennfalt et al. (2023) Visualising and semi-quantitatively measuring brain fluid pathways, including meningeal lymphatics, in humans using widely available MRI techniquesSiedlinski et al. (2023) Genetic analyses identify brain structures related to cognitive impairment associated with elevated blood pressureValdes Hernandez et al. (2023) Paranasal sinus occupancy assessed from magnetic resonance images-associations with clinical indicators in patients with systemic lupus erythematosusWang et al. (2023) Baseline brain imaging signs in patients with ischaemic stroke by the presence of atrial fibrillation: the ENCHANTED trialWardlaw et al. (2023) Even more benefit with endovascular treatment for patients with acute ischaemic stroke: MR CLEAN-LATEWardlaw et al. (2023) Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel DiseaseThe Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical TrialWhittington et al. (2023) Noninvasive In Vivo Thrombus Imaging in Patients With Ischemic Stroke or Transient Ischemic Attack Publications 20222023Alzahrani et al (2023) Assessing Brain Tissue Viability on Nonenhanced Computed Tomography After Ischemic StrokeClancy et al (2023) Are neuropsychiatric symptoms a marker of small vessel disease progression in older adults? Evidence from the Lothian Birth Cohort 1936Clancy et al. (2023) Neuropsychiatric symptoms as a sign of small vessel disease progression in cognitive impairmentLam et al (2022) The global burden of cerebral small vessel disease in low- and middle-income countries - a systematic review and meta-analysis DecemberPersson et al. (2022) Could dexmedetomidine be repurposed as a glymphatic enhancer?Lahna et al. (2022) Venous Collagenosis as Pathogenesis of White Matter HyperintensityNovemberBernal et al (2022) Assessment of perivascular space filtering methods using a three-dimensional computational model October Nanayakkara et al (2022) Increased brain volumetric measurement precision from multi-site 3D T1-weighted 3 T magnetic resonance imaging by correcting geometric distortionsvan den Brink et al. (2022) CADASIL Affects Multiple Aspects of Cerebral Small Vessel Function on 7T-MRIWiseman et al (2022) Retinal capillary microvessel morphology changes are associated with vascular damage and dysfunction in cerebral small vessel diseaseLam er al (2022) The global burden of cerebral small vessel disease in low- and middle-income countries - a systematic review and meta-analysis September Jochems et al. (2022) Longitudinal Changes of White Matter Hyperintensities in Sporadic Small Vessel Disease: A Systematic Review and Meta-analysis AugustCharidimou et al (2022) The Boston criteria version 2.0 for cerebral amyloid angiopathy: a multicentre, retrospective, MRI–neuropathology diagnostic accuracy studyBall et al (2022) Predictors of post-stroke cognitive impairment using acute structural MRI neuroimaging: A systematic review and meta-analysisQuick et al (2022) Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat modelWhiteley et al. (2022) Clinical Diagnosis and Magnetic Resonance Imaging in Patients With Transient and Minor Neurological Symptoms: A Prospective Cohort StudyMarkus et al. (2022) Framework for Clinical Trials in Cerebral Small Vessel Disease (FINESSE) A ReviewBarnes et al. (2022) Topological relationships between perivascular spaces and progression of white matter hyperintensities: A pilot study in a sample of the Lothian Birth Cohort 1936Li et al. (2022) Deep attention super-resolution of brain magnetic resonance images acquired under clinical protocolsMair et al. (2022) External Validation of e-ASPECTS Software for Interpreting Brain CT in StrokeJochems et al. (2022) Associations of Peak-Width Skeletonized Mean Diffusivity and Post-Stroke Cognition JulyWardlaw et al (2022) Accuracy of Automated Computer-Aided Diagnosis for Stroke Imaging: A Critical Evaluation of Current EvidenceLorenzini et al (2022) The Open-Access European Prevention of Alzheimer’s Dementia (EPAD) MRI dataset and processing workflowLee et al (2022) Choroid plexus tissue perfusion and blood to CSF barrier function in rats measured with continuous arterial spin labelingBall et al. (2022) Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysis June Zhou et al (2002) Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure targetMonte et al (2022) Characterization of perivascular space pathology in a rat model of cerebral small vessel disease by in vivo magnetic resonance imagingIbitoye et al (2022) A link between frontal white matter integrity and dizziness in cerebral small vessel diseaseWhittaker et al (2022) Systematic Review of Cerebral Phenotypes Associated With Monogenic Cerebral Small-Vessel DiseaseKaczynski et al (2022) 18 F-NaF PET/MRI for Detection of Carotid Atheroma in Acute Neurovascular SyndromeMishra et al (2022) Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate MayMishra et al (2022) Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidateRudilosso et al (2022) Prevalence and Significance of the Vessel-Cluster Sign on Susceptibility-Weighted Imaging in Patients With Severe Small Vessel DiseaseQuick et al (2022) Loss of the heterogeneous expression of flippase ATP11B leads to cerebral small vessel disease in a normotensive rat model AprilZhao et al (2022) Prenatal disruption of blood-brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammationBiesbroek et al (2022) Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic strokeBrouwer et al (2022) Genetic variants associated with longitudinal changes in brain structure across the lifespanWardlaw et al (2022) Accuracy of Automated Computer-Aided Diagnosis for Stroke Imaging: A Critical Evaluation of Current EvidenceLuciano et al (2022) Mediterranean-Type Diet and Brain Structural Change from 73 to 79 Years in the Lothian Birth Cohort 1936Biesbroek et al (2022) Network impact score is an independent predictor of post-stroke cognitive impairment: A multicenter cohort study in 2341 patients with acute ischemic strokeJochems et al (2022) Contribution of white matter hyperintensities to ventricular enlargement in older adultsWardlaw & Liebeskind (2022)Not Just Blood: Brain Fluid Systems and Their Relevance to Cerebrovascular DiseasesSliz et al (2022) Circulating Metabolome and White Matter Hyperintensities in Women and MenClancy et al (2022) Impact of Small Vessel Disease Progression on Long-term Cognitive and Functional Changes After Stroke MarchMeinel et al (2022) Letter by Meinel et al. regarding article, "Incidental findings on 3 T neuroimaging: cross‑sectional observations from the population‑based Rhineland Study"Wheater et al (2022) DNA methylation in relation to gestational age and brain dysmaturation in preterm infants FebruaryWiseman et al (2022) Measuring axial length of the eye from magnetic resonance brain imagingClancy et al (2022) Impact of Small Vessel Disease Progression on Long-term Cognitive and Functional Changes After StrokeFletcher et al (2022) Thoracic Aortic 18 F-Sodium Fluoride Activity and Ischemic Stroke in Patients With Established Cardiovascular DiseaseChen et al (2022) Perivascular space in Parkinson's disease: Association with CSF amyloid/tau and cognitive declineCraig et al (2022) Prevalence of dementia in ischaemic or mixed stroke populations: systematic review and meta-analysisBarisano et al (2022) Blood-brain barrier link to human cognitive impairment and Alzheimer's DiseaseWardlaw, Benveniste and Williams (2022) Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical StudiesJanuaryTunnage et al (2022) Pre-hospital transdermal glyceryl trinitrate in patients with stroke mimics: data from the RIGHT-2 randomised-controlled ambulance trial. Sliz et al (2022) Circulating Metabolome and White Matter Hyperintensities in Females and MalesMcCartney et al (2022) Blood-based epigenome-wide analyses of cognitive abilitiesChen et al (2022) Perivascular space in Parkinson's disease: Association with CSF amyloid/tau and cognitive declineMoullaali et al (2022) Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data Publications 2021DecemberBlair et al (2021) Effects of Cilostazol and Isosorbide Mononitrate on Cerebral Hemodynamics in the LACI-1 Randomized Controlled TrialConosole et al (2021) DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging November Moullaali et al (2021) Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient dataStringer et al (2021) Tracer kinetic assessment of blood-brain barrier leakage and blood volume in cerebral small vessel disease: Associations with disease burden and vascular risk factors OctoberWardlaw et al (2021) Cerebral Vascular Dysfunctions Detected in Human Small Vessel Disease and Implications for Preclinical StudiesZhang et al (2021) Relationship between inferior frontal sulcal hyperintensities on brain MRI, ageing and cerebral small vessel diseasede Havenon et al (2021) Cilostazol for Secondary Stroke Prevention: History, Evidence, Limitations, and PossibilitiesChagnot et al (2021) Magnetic Resonance Imaging of Blood-Brain Barrier permeability in DementiaJiménez-Sánchez et al (2021) Sex Differences in Cerebral Small Vessel Disease: A Systematic Review and Meta-AnalysisGreen C et al (2021) Hair glucocorticoids are associated with childhood adversity, depressive symptoms and reduced global and lobar grey matter in Generation Scotland SeptemberVynckier et al (2021) Phenotypes of Chronic Covert Brain Infarction in Patients With First-Ever Ischemic Stroke: A Cohort StudyBall et al (2021) Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysisBackhouse et al (2021) Early life predictors of late life cerebral small vessel disease in four prospective cohort studiesShi et al (2021) Identification of plasma proteins relating to brain neurodegeneration and vascular pathology in cognitively normal individualsOh et al (2021) Fixel-Based Analysis Effectively Identifies White Matter Tract Degeneration in Huntington’s DiseaseWardlaw et al (2021) Reply to: Rethink the classical view of cerebrospinal fluid productionHamilton et al (2021) Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohortAl-Shahi Salman et al (2021) Effects of Antiplatelet Therapy After Stroke Caused by Intracerebral HemorrhageExtended Follow-up of the RESTART Randomized Clinical TrialSoSTART Collaboration (2021) Effects of oral anticoagulation for atrial fibrillation after spontaneous intracranial haemorrhage in the UK: a randomised, open-label, assessor-masked, pilot-phase, non-inferiority trial AugustXia et al (2021) Early decompressive hemicraniectomy in thrombolyzed acute ischemic stroke patients from the international ENCHANTED trialWeather et al (2021) Birth weight is associated with brain tissue volumes seven decades later but not with MRI markers of brain ageingJulyWardlaw (2021) A Stroke Is a Stroke, With or Without a Visible InfarctProcter et al (2021) Interplay between brain pericytes and endothelial cells in dementiaHabota et al (2021) Cohort profile for the STratifying Resilience and Depression Longitudinally (STRADL) study: A depression-focused investigation of Generation Scotland, using detailed clinical, cognitive, and neuroimaging assessments [version 2; peer review: 2 approved]Bernal et al (2021) Selective Motion Artefact Reduction via Radiomics and k-space Reconstruction for Improving Perivascular Space Quantification in Brain Magnetic Resonance ImagingBlair et al (2021) Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target projectWardlaw et al (2021) Reply to: Rethink the classical view of cerebrospinal fluid productionHamilton et al (2021) Cerebral small vessel disease burden and longitudinal cognitive decline from age 73 to 82: the Lothian Birth Cohort 1936 June Hamilton & Wardlaw (2021) Response to Schroeter ML, Letter, Small vessel disease and social cognitionStringer et al (2021) A Comparison of CVR Magnitude and Delay Assessed at 1.5 and 3T in Patients With Cerebral Small Vessel DiseaseWiegertjes et al (2021) Diffusion-weighted imaging lesions and risk of recurrent stroke after intracerebral haemorrhageZhou et al (2021) Thrombolysis outcomes according to arterial characteristics of acute ischemic stroke by alteplase dose and blood pressure targetPortilla-Fernandez et al (2021) Meta-analysis of epigenome-wide association studies of carotid intima-media thicknessZhu et al (2021) Alzheimer's pathogenic mechanisms and underlying sex differenceDatasetsValdés Hernández et al (2021) White Matter Hyperintensities Evolution Patterns 1 Year Post-lacunar Stroke and their association with post-stroke cognitionCastorina et al (2021) Metrics for quality control of results from super-resolution machine-learning algorithms – Data extracted from publications in the period 2017- May 2021Morrsison & Valdés Hernández (2021) Systematic Review and Meta-Analysis on incidence and risk of stroke in individuals with long-term exposure to air pollutants MayMorrison et al (2021) Potential recruitment into a clinical trial of vascular secondary prevention medications in cerebral small vessel disease, based on concomitant medication useStewart et al (2021) Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-AnalysisManning et al (2021) Sources of systematic error in DCE-MRI estimation of low-level blood-brain barrier leakageWardlaw et al (2021) ESO Guideline on covert cerebral small vessel diseasevan der Brink et al (2021) Zooming in on cerebral small vessel function in small vessel diseases with 7T MRI: Rationale and design of the “ZOOM@SVDs” studyBuchanan et al (2021) Comparison of structural MRI brain measures between 1.5 and 3 T: Data from the Lothian Birth Cohort 1936DatasetsBernal (2021) Systematic review of signal post-processing methods in blood-brain barrier dysfunction assessments via dynamic-contrast enhanced magnetic resonance imagingHumphreys & Valdés Hernández (2021) Systematic Review and Meta-Analysis on the Impact of Polycyclic Aromatic Hydrocarbons Exposure in Cognitive Function and Neurodegeneration in Humans Valdés Hernández (2021) Human Brain Atlases across the lifespan – Anatomical Segmentations AprilMadole et al (2021) Aging-Sensitive Networks Within the Human Structural Connectome Are Implicated in Late-Life Cognitive DeclinesBernal et al (2021) A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakageIngala et al (2021) Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort MarchValdes-Hernandez et al (2021) Post-stroke Cognition at 1 and 3 Years Is Influenced by the Location of White Matter Hyperintensities in Patients With Lacunar StrokeTaylor et al (2021) Genetic basis of lacunar stroke: a pooled analysis of individual patient data and genome-wide association studiesValdes-Hernandez et al (2021) Lacunar Stroke Lesion Extent and Location and White Matter Hyperintensities Evolution 1 Year Post-lacunar StrokeClancy et al (2021) Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysisLiebeskind & Wardlaw (2021). Imaging advances: acute-on-chronic stroke FebruaryVerdelho et al (2021) Cognitive impairment in patients with cerebrovascular disease: A white paper from the ESO Dementia CommitteeVerdelho et al (2021) Cerebrovascular disease in patients with cognitive impairment: A white paper from the ESO dementia committee – A practical point of view with suggestions for the management of cerebrovascular diseases in memory clinicsZhou et al (2021) Low- versus Standard-dose Alteplase in Acute Lacunar Ischemic Stroke: The ENCHANTED TrialGreen et al (2021) Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorderRodriguez et al (2021) Association between Computed Tomographic Biomarkers of Cerebral Small Vessel Diseases and Long-Term Outcome after Spontaneous Intracerebral HemorrhageStringer et al (2021) A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel DiseasePapanastasiou et al (2021) Pharmacokinetic modelling for the simultaneous assessment of perfusion and 18F-flutemetamol uptake in cerebral amyloid angiopathy using a reduced PET-MR acquisition time: Proof of conceptExpand allCollapse allView all publication of the Small Vessel Disease Research group at the Edinburgh Research ExplorerSmall Vessel Disease Research publications- Edinburgh Research Explorer (external link) Books / Book chaptersGorelick PB, Testai FD, Hankey GJ, Wardlaw JM (2021). "Hankey's Clinical Neurology" (3rd Edition) Link 20% discount available with a flyerDoubal F, Poggesi A, Pantoni L, Wardlaw JM (2020). Section 4 Vascular Disease, Chapter 21, Small vessel disease. In Brayne C, Feigin V, Launer L, Logroscino G, eds. Oxford Textbook of Neurologic and Neuropsychiatric Epidemiology. Oxford University Press, Oxford, 2020. DOI link: 10.1093/med/9780198749493.001.0001Rekik I, Adeli E, Park SH, Valdés Hernández M del C (2020). Predictive Intelligence in Medicine. Third International Workshop, PRIME 2020, Held in Conjunction with MICCAI 2020. LinkProtocol research publicationsINVESTIGATE@SVDs study protocolBlair et al (2021) Imaging neurovascular, endothelial and structural integrity in preparation to treat small vessel diseases. The INVESTIGATE-SVDs study protocol. Part of the SVDs@Target project. Publication linkMild Stroke Study 3 (MSS3) protol research publicationClancy et al (2020). Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3. Publication link - Edinburgh Research ExplorerLACI-2 protocol research publicationWardlaw et al (2020). Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease. Publication link - Edinburgh Research ExplorerLACI-1 publication presenting key resultsBlair et al (2019). Tolerability, safety and intermediary pharmacological effects of cilostazol and isosorbide mononitrate, alone and combined, in patients with lacunar ischaemic stroke: The LACunar Intervention-1 (LACI-1) trial, a randomised clinical trial. Publication link - Edinburgh Reserach ExplorerRates, Risks and Routes to Reduce Vascular Dementia (R4VaD) key publicationBackhouse et al (2019). Rates, risks and routes to reduce vascular dementia (R4VAD). Publication link Read more about our researchOur researchSystematic reviews2021Ball et al (2021) Predicting post-stroke cognitive impairment using acute CT neuroimaging: A systematic review and meta-analysis Publication linkClancy et al (2021) Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis. Publication linkStringer et al (2021). A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease. Publication linkMorgan et al (2021). 4D flow MRI for non-invasive measurement of blood flow in the brain: a systematic review. Publication linkSleight (2021). Cerebrovascular reactivity measurement using magnetic resonance imaging: a systematic review. Publication linkVerdelho et al (2021). Cerebrovascular disease in patients with cognitive impairment: A white paper from the ESO Dementia Committee. Publication linkBest et al (2021). Development of imaging-based risk scores for prediction of intracranial haemorrhage and ischaemic stroke in patients taking antithrombotic therapy after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies. Publication linkMadole et al (2021). Aging-sensitive networks within the human structural connectome are implicated in late-life cognitive declines. Publication link 2020Hamilton et al. (2020). Cognitive impairments in sporadic cerebral small vessel disease (SVD): a systematic review and meta-analysis of cohorts with stroke, dementia and non-clinical presentations of SVD. Publication linkZhang et al (2020). The application of optical coherence tomography angiography in cerebral small vessel disease, ischemic stroke, and dementia: a systematic review. Publication linkDoubal et al (2020). Response by Doubal et al to Letter Regarding Article, "Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis. Publication linkHamilton et al (2020). Cognitive impairment in sporadic cerebral small vessel disease: a systematic review and meta‐analysis. Publication linkBalakrishnan et al (2020) Automatic segmentation of white matter hyperintensities from brain magnetic resonance images in the era of deep learning and big data – a systematic review. Publication linkAppleton et al (2020). Intracranial bleeding after reperfusion therapy in acute ischaemic stroke patients randomized to glyceryl trinitrate vs. control: An individual patient data meta-analysis. Publication linkSaba et al (2020). Multi-national survey of current practice from imaging to treatment of atherosclerotic carotid stenosis. Publication linkStewart et al (2020). Associations between white matter hyperintensity burden, cerebral blood flow and transit time in small vessel disease: an updated meta-analysis. Publication linkClancy et al (2020). Clinical management of cerebral small vessel disease: a call for a holistic approach. Publication linkWardlaw et al (2020). Brain atrophy in cerebral small vessel diseases: extent, consequences, technical limitations and perspectives: the HARNESS initiative. Publication linkMcHutchison et al (2020). Cilostazol for secondary prevention of stroke and cognitive decline: Systematic review and meta-analysis. Publication linkWheater et al (2020). DNA methylation and brain structure and function across the life course: A systematic review. Publication linkSweeney et al (2020). Perivascular Spaces in the Brain: anatomy, physiology, and pathology. Publication link 2019Francis et al (2019). Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis. Publication linkMoullaali et al (2019). Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood pressure in Acute Stroke Collaboration (BASC). Publication linkSmith et al (2019). Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration. Publication linkThrippleton et al (2019). Quantifying blood-brain barrier leakage in small vessel disease: Review and consensus recommendations. Publication linkLindekleiv et al (2019). Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke. Publication linkWardlaw et al (2019). Small vessel disease: mechanisms and clinical implications. Publication link 2018Backhouse et al (2018). Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis. Publication linkPellegrini et al (2018) Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review. Publication linkShi et al (2018). Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review. Publication linkGeorgakis et al (2018). WMH and long-term outcomes in ischemic stroke: a systematic review and meta-analysis. Publication linkGibson et al (2018). Potentially serious incidental findings on brain and body magnetic resonance imaging of apparently asymptomatic adults: systematic review and meta-analysis. Publication link 2017Abbott et al (2017). Optimizing the definitions of stroke, transient ischemic attack, and infarction for research and application in clinical practice. Publication linkVan Veluw et al (2017). Detection, risk factors, and functional consequences of cerebral microinfarcts. Publication linkMollison et al (2017). The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis. Publication linkBlair et al (2017). Advanced neuroimaging of cerebral small vessel disease. Publication linkDickie et al (2017). Whole brain magnetic resonance image atlases: a systematic review of existing atlases and caveats for use in population imaging. Publication linkAlso republished as a chapter in the following e-book: Dojat M, Niessen W, Kennedy DN eds. MAPPING: MAnagement and Processing of Images for Population ImagiNG. Lausanne: Frontiers Media SA 2017. Publication linkBackhouse et al (2017). Early life risk factors for cerebrovascular disease: A systematic review and meta-analysis. Publication linkMcGrory et al (2017). The application of retinal fundus camera imaging in dementia: A systematic review. Publication link Read other systematic reviews - SVD Research Edinburgh Research ExplorerMeta-analyses2021Stewart et al (2021) Associations Between White Matter Hyperintensity Burden, Cerebral Blood Flow and Transit Time in Small Vessel Disease: An Updated Meta-Analysis. Publication linkClancy et al (2021) Neuropsychiatric symptoms associated with cerebral small vessel disease: a systematic review and meta-analysis. Publication linkJimenez Sanchez et al (2021). Sex differences in cerebral small vessel disease: a systematic review and meta-analysis. Publication link 2020Stewart et al (2020). Associations between white matter hyperintensity burden, cerebral blood flow and transit time in small vessel disease: an updated meta-analysis. Publication linkHamilton et al (2020). Cognitive impairments in sporadic cerebral small vessel disease (SVD): a systematic review and meta-analysis of cohorts with stroke, dementia and non-clinical presentations of SVD. Publication linkMcHutchison et al (2020). Cilostazol for secondary prevention of stroke and cognitive decline: Systematic review and meta-analysis. Publication linkHamilton et al (2020). Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis. Publication linkAppleton et al (2020). Intracranial bleeding after reperfusion therapy in acute ischaemic stroke patients randomized to glyceryl trinitrate vs. control: An individual patient data meta-analysis. Publication link2019Jia et al (2019). Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group. Publication linkMoullaali et al (2019). Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood pressure in Acute Stroke Collaboration (BASC). Publication linkFrancis et al (2019). Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis. Publication link 2018Gibson et al (2018). Potentially serious incidental findings on brain and body magnetic resonance imaging of apparently asymptomatic adults: systematic review and meta-analysis. Publication linkHacke et al (2018). Effects of alteplase for acute stroke according to criteria defining the European Union and United States marketing authorizations: Individual-patient-data meta-analysis of randomized trials. Publication linkBackhouse et al (2018). 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